Symptoms resolution in depression might not equal to functional improvement, in a pooled analysis of 1419 patients with depression, the combined symptomatic & functional remission is as low as 23%?
There are consistent evidence to show positive correlation cognitive function and functional outcomes in depression.
Modafinil has Level I evidence (Replicated placebo-controlled trial evidence with demonstration of independent effect) in improving cognitive symptoms in all domain (Learning/memory, executive function, processing speed & attention/concentration)
The rate of emotional blunting was reported by nearly half of the patients at 46% taking SSRls/SNRls; The experience of emotional blunting was slightly more frequent in men than women (52% versus 44%)
The average reported incidence of sexual dysfunction among patient with MDD receiving SSRIs is above 50%.
