In your clinical experience, what are the most important residual symptoms for risk of relapse? Does the dosing of vortioxetine differ? Whether it is the first,second or third line treatment? When a patient with depression relapses as part of their MDD, should the clinician expect to return the patient back to functioning? In that context, do they need to use a higher dosing? Which psychiatric comorbidities in depression, do you find the most difficult to treat? How long should the antidepressant be continued after achieving remission? patients who have depression and who have a history of substance abuse or alcohol abuse is there any limitations with using vortioxetine in such a case? Do you think the effect of vortioxetine in patients with depression and history of trauma is unique? Any considerations for treatment? How effective is vortioxetine for obese patients with MSS and cardiovascular comorbidity? Is there a risk of weight gain or other side effects? What is the best dose of vortioxetine for treatment of MDD with comorbid alcohol/drug abuse disorder? How can we treat emotional blunting after long term treatment of SSRI What is the experience of Dr Montes with combined Autism Spectrum Disorder and MDD with regards to vortioxetine prescription? What is the best safe vortioxetine dose for geriatric patients? What are the most common side effects?